Are blood cultures necessary in adults with cellulitis?

Cellulitis is frequently seen in ambulatory care settings and is often responsive to empiric therapy directed against Staphylococcus aureus and group A b-hemolytic streptococcus. Ideally, blood culture susceptibility by offending pathogens should direct antimicrobial therapy, but their low yield in skin infections may render them clinically useless. We therefore reviewed the available evidence on this topic.